北京優尼康生物科技有限公司主要經營進口、國產生物科研儀器、試劑及耗材，提供技術服務的生物公司之一。現經營的品牌及相關產品如下：

德國Griner培養板、培養皿、離心管、凍存管、培養瓶、接種環、接種針等；

美國Wheaton 勻漿器、組織研磨器、雙側壁細胞培養瓶、懸浮細胞培養瓶、細胞專用攪拌器、安培瓶等玻璃儀器。

美國kimble 藍蓋瓶、勻漿器、離心管，巴氏吸管等玻璃儀器；

加拿大Labplas 的無菌采樣袋、均值袋；

美國Nalgene 過濾裝置、塑料廣口瓶、放水桶、低溫冰盒、低溫標簽、記號筆、離心管、凍存管、便攜液氮罐、無菌培養基瓶、手動真空泵等

美國ABI PCR板、PCR管、PCR蓋子、八連拍管、膜等

德國Brand 移液器，電動移液器，瓶口分配等

德國艾本德eppendorf 移液器、分配器等

法國Hyphen Biomed 的出血、凝血類試劑 ；

美國BioProducts MD 的PEDF(人眼色素上皮衍生因子)；

德國IBL international 新蝶呤試劑盒、兒茶酚胺試劑盒；

美國TYLER 的篩分儀；

BD公司的基質膠,細胞篩網等;

法國Interscience 均質器、重量稀釋器、自動螺旋接種儀、均值袋、均值夾、開袋器、架子等

德國Wiggens 攪拌器、培養箱、振蕩器、蒸發器（氮吹儀）菌落計數器本生燈、均質器等

德國Chemvck 防腐隔膜泵、無油泵、真空泵、蠕動泵等

瑞士Keller 小型快速玻璃珠滅菌器、玻璃珠等

美國Millpore 細胞電阻儀、超濾管、膜、針頭濾器等

美國 BioSpec研磨珠均質器、手持勻漿機等

自產鎳洛合金接種環、接種針、核酸染料等

Clozapine-N-oxide (CNO) is a metabolite of clozapine, which reduces the density of 5-HT2 receptor in rat primary cortical cells. [1] Clozapine-N-oxide (CNO) also activates an evolved M3-muscarinic receptor and then can be used in chemogenetics. [2]

Clozapine is a known atypical antipsychotic medication used in the treatment of schizophrenia. The two major metabolites of clozapine are norclozapine and clozapine-N-oxide (CNO) [3]. Clozapine is also formed from its N-oxide metabolite. It means that a reversible metabolic pathway exists for clozapine and clozapine-N-oxide (CNO) [4]. In rat primary cortical cells and SHS5Y5 neuroblastoma cells, a significant decrease was found for 5-HT2 receptor density with 200 ng/ml clozapine-N-oxide (CNO) [1]. about the method of identification, reversed-phase HPLC has been reported to detect clozapine and its two major metabolites in human plasma[5].

References:
1. P. Heiser, E. Schulte, C. Hausmann, R. Becker, H. Remschmidt, J. C. Krieg and H. Vedder, Prog Neuropsychopharmacol Biol Psychiatry 2004, 28, 297-302.
2. Armbruster BN1, Li X, Pausch MH, et al. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8.
3. S. A. Volpicelli, F. Centorrino, P. R. Puopolo, J. Kando, F. R. Frankenburg, R. J. Baldessarini and J. G. Flood, Clin Chem 1993, 39, 1656-1659.
4. M. W. Jann, Y. W. Lam and W. H. Chang, Arch Int Pharmacodyn Ther 1994, 328, 243-250.
5. A. Avenoso, G. Facciola, G. M. Campo, A. Fazio and E. Spina, J Chromatogr B Biomed Sci Appl 1998, 714, 299-308.