"上海博耀生物銷售XIAP (3B6) Rabbit mAb #2045，CST原裝品質，價格優惠，訂購XIAP (3B6) Rabbit mAb #2045，詳情請咨詢銷售人員

"上海博耀生物銷售XIAP (3B6) Rabbit mAb #2045，CST原裝品質，價格優惠，訂購XIAP (3B6) Rabbit mAb #2045，詳情請咨詢銷售人員！
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產品名稱：XIAP (3B6) Rabbit mAb #2045
貨號：2045
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型： Monoclonal
規格：

No.	Size	Price
2045P	40 ul (4 western blots)	詢價
2045S	100 ul (10 western blots)	詢價

抗體應用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H Mk	Endogenous	53	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度： XIAP (3B6) Rabbit mAb detects endogenous levels of XIAP. No cross reactivity was observed with other IAP family members.
來源及純化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to a region surrounding serine 245 of human XIAP.
抗體背景：

The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).

關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}

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