滕州市浩瀚色譜儀器技術服務有限公司，探討職業性急性1,2-二氯乙烷(1,2-DCE)中毒患者血中二氯乙烷檢測的臨床意義。方法選擇收治的職業性急性1,2-DCE中毒病例38例,隨機對其中12例病例進行血中毒物檢測;檢測方法為頂空氣相色譜-質譜法。結果12例患者中有7例患者在發病6~18h送血標本檢出1,2-DCE成份,其中3例同時檢出丙酮成份;另外5例在發病24~72h送血檢測,均未檢出1,2-DCE成份,僅檢出丙酮成份,(1例檢出二氯甲烷、甲苯,1例檢出二硫化碳)。結論急性1,2-DCE中毒患者應早期進行血毒物檢測,1,2-DCE陽性對明確病因及臨床診斷有重要價值。

1,2-二氯乙烷中毒患者血液毒物色譜分析 圖片：


Chromatographic analysis of blood poisons in patients with 1,2-dichloroethane poisoning
Chromatographic analysis of blood poisons in patients with 1,2-dichloroethane poisoning

Stationary phase: 5% phenyl-methyl polysiloxane
Specification: 60m*0.25mm*0.25um
Model: HH-5
Application: GBZ/T 286-2016 Determination of 1,2-dichloroethane in blood by gas chromatography-mass spectrometry


Tengzhou Haohao Chromatography Instrument Technology Service Co., Ltd. explored the clinical significance of detection of dichloroethane in blood of patients with occupational acute 1,2-dichloroethane (1,2-DCE) poisoning. Methods A total of 38 cases of occupational acute 1,2-DCE poisoning were selected. Blood poisoning was detected in 12 cases. The detection method was headspace gas chromatography-mass spectrometry. Results Among the 12 patients, 7 patients were found to have 1,2-DCE in the blood samples from 6 to 18 hours after the onset of symptoms. 3 of them were detected with acetone at the same time. The other 5 patients were tested for blood supply at 24 to 72 hours after the onset. The 1,2-DCE component was detected, and only the acetone component was detected (1 case of dichloromethane, toluene, and 1 case of carbon disulfide). Conclusion Patients with acute 1,2-DCE poisoning should be tested for blood poisoning at an early stage. 1,2-DCE positive is of great value for definite etiology and clinical diagnosis.

Chromatographic analysis of blood poisons in patients with 1,2-dichloroethane poisoning